منابع مشابه
Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors.
The family of receptors that transmit signals through the activation of heterotrimeric GTP-binding proteins (G proteins) constitutes the largest group of cell surface proteins involved in signal transduction. These receptors participate in a broad range of important biological functions and are implicated in a number of disease states. More than half of all drugs currently available influence G...
متن کاملRACK1, scaffolding a heterotrimeric G protein and a MAPK cascade.
Scaffold proteins of mitogen-activated protein kinase (MAPK) cascades play crucial roles in determining signal specificity, amplitude, and duration in yeast and mammals. Recently, RACK1 was identified as the first plant MAPK scaffold protein that connects heterotrimeric G protein with a MAPK cascade to form a unique signaling pathway in plant immunity.
متن کاملREGULATION OF PROTEIN SYNTHESIS g 15 HRI
The influence of divalent cations Mg 2+, Mn 2+, and Ca 2+ on the cyclic-AMP-independent protein kinases of the h e i n e r e g u l a t e d and d o u b l e s t r a n d e d R N A a c t i v a t e d t r a n s l a t i o n a l i n h i b i t o r y prote in kinases on sel f p h o s p h o r y l a t i o n and he t e rophospho ry l a t i on of the substrate (the 3g 000-dalton subunit of initiation factor ...
متن کاملRegulation of G protein-coupled receptor trafficking.
G protein-coupled receptors (GPCRs) mediate cellular responses to diverse extracellular stimuli to play a vital role in the control of physiology and behaviour. GPCR trafficking is of fundamental importance for the regulation of GPCRs signaling. In this mini review, we will discuss some of the recent findings on the mechanisms that regulate GPCR trafficking, which include (i) large dense-core v...
متن کاملPhysiological regulation of G protein-linked signaling.
Heterotrimeric G proteins in vertebrates constitute a family molecular switches that transduce the activation of a populous group of cell-surface receptors to a group of diverse effector units. The receptors include the photopigments such as rhodopsin and prominent families such as the adrenergic, muscarinic acetylcholine, and chemokine receptors involved in regulating a broad spectrum of respo...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2007
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1210407